Chris Whitty, chief medical officer for England, was right to pour cold water on the idea that, over the months, the virus has mutated into something milder. Yes, adaptive changes occur, but all available data suggests we’re facing the same virus since the start of the pandemic
In early January, the first genome sequence of Sars-CoV-2 – the virus that causes Covid-19 – was released under the moniker “Wuhan-1”. This string of 30,000 letters (the A, T, C and Gs of the genetic code) marked day one in the race to understand the genetics of this newly discovered coronavirus.
Now, a further 100,000 coronavirus genomes sampled from Covid-19 patients in over 100 countries have joined Wuhan-1. Geneticists around the world are mining the data for answers. Where did Sars-CoV-2 come from? When did it start infecting humans? How is the virus mutating – and does it matter? Sars-CoV-2 genomics, much like the virus itself, went big and went global.
The term mutation tends to conjure up images of dangerous new viruses with enhanced abilities sweeping across the planet. And while mutations constantly emerge and sometimes sweep – early mutations in Sars-CoV-2 have made their way around the world as the virus spread almost unnoticed – mutations are a perfectly natural part of any organism, including viruses. The vast majority have no impact on a virus’s ability to transmit or cause disease.
A mutation just means a difference; a letter change in the genome. While the Sars-CoV-2 population was genetically essentially invariant when it jumped into its first human host in late 2019, over 13,000 of these changes are now found in the 100,000 Sars-CoV-2 sequenced to date.
Yet any two viruses from any two patients anywhere in the world differ on average by only ten letters. This is a tiny fraction of the total 30,000 characters in the virus’s genetic code and means that all Sars-CoV-2 in circulation can be considered part of a single clonal lineage.
Slowly mutating
It will take some time for the virus to acquire substantial genetic diversity. Sars-CoV-2 mutates fairly slowly for a virus, with any lineage acquiring a couple of changes every month; two to six-fold lower than the number of mutations acquired by influenza viruses over the same period.Still, mutations are the bedrock on which natural selection can act. Most commonly mutations will render a virus non-functional or have no effect whatsoever.
Yet the potential for mutations to affect transmissibility of Sars-CoV-2 in its new human hosts exists. As a result, there have been intense efforts to determine which, if any, of the mutations identifiable since the first Sars-CoV-2 genome was sequenced in Wuhan may significantly alter viral function.
An infamous mutation in this context is an amino acid change in the Sars-CoV-2 spike protein, the protein that gives coronaviruses their characteristic crown-like projections and allows it to attach to host cells. This single character change in the viral genome – termed D614G – has been shown to increase virus infectivity in cells grown in the lab, though with no measurable impact on disease severity.
Simply carried along
D614G is not the only mutation found at high frequency. Other mutations exist in the spike protein while myriad others seem induced by the activity of our own immune response. At the same time, there remains no consensus that these, or any others, are significantly changing virus transmissibility or virulence. Most mutations are simply carried along as Sars-CoV-2 continues to successfully spread.
While adaptive changes may yet occur, all the available data at this stage suggests we’re facing the same virus since the start of the pandemic. Chris Whitty, chief medical officer for England, was right to pour cold water on the idea that the virus has mutated into something milder than the one that caused the UK to impose a lockdown in March.
Possible decreases in symptom severity seen over the summer are probably a result of younger people being infected, containment measures (such as social distancing) and improved treatment rather than changes in the virus itself. However, while Sars-CoV-2 has not significantly changed to date, we continue to expand our tools to track and trace its evolution, ready to keep pace.
Courtesy: WEF______________________________________________
