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THURSDAY, 18 JUNE 2026

The era of viral dominance

Driven by rapid mutation rates, high transmissibility, and genetic diversity, viruses have become the planet’s most abundant biological entities

PACHU MENON
Published Jun 14
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The era of viral dominance

The ‘Bundibugyo Virus Disease’ (BVD) outbreak in the Democratic Republic of Congo which continues to evolve rapidly once again brings to fore the stark realities of an age where microbial supremacy dictates our ecological and medical realities. Viral outbreaks are the new normal!

The continuous emergence of novel pathogens from the emerging and re-emerging pathogens and diseases to future threats highlights the escalating threat of zoonotic spillovers.

Ever since the COVID-19 pandemic, the mutating Corona virus has been a subject of worldwide speculation, which has necessitated global health authorities to constantly track and evaluate emerging variants.

According to the World Health Organization (WHO), “Viruses are the most abundant biological entities on the planet. They permeate every ecosystem, exist on every surface, and even live within the human microbiome. While many are harmless or even beneficial, infectious viruses remain an ever-present reality requiring vigilance.”

As human mobility and urbanization increase, viruses continually adapt and mutate. Health organizations actively track potential threats to public health.

Urbanization drives virus adaptation and mutation by creating dense human networks, changing local ecosystems, and increasing interactions between humans and wildlife. These dense, connected environments act as massive ‘incubators’ that accelerate virus evolution and transmission.

We live in an age of viral dominance primarily because human activity has fundamentally altered ecological barriers. Rapid urbanization, global connectivity, and climate change create perfect conditions for viruses to spill over from animals, mutate rapidly, and spread across the globe within days.

A majority of the emerging infectious diseases are zoonotic. Deforestation, intensive agriculture, and land-use changes push humans and livestock into closer contact with wildlife, such as bats and rodents, increasing the chances of viruses jumping the species barrier.

For instance, the ‘Nipah’ virus outbreaks and Kerala are deeply intertwined because the state has experienced recurrent spillover events since 2018, mainly in northern districts like Kozhikode, Malappuram, and Palakkad.

Kerala’s unique vulnerability and association with the virus are driven by specific ecological and epidemiological factors.

Dense forests in the Western Ghats provide a thriving habitat for ‘Pteropus’ fruit bats, which are the natural reservoirs for the virus. Human-animal interaction is high, often through the consumption of fruits or palm sap potentially contaminated by bats.

High population density facilitates the spread of infection once it emerges. State health authorities issue a seasonal Nipah alert from April to September, as outbreaks often align with bat breeding and fruiting seasons.  

Moreover, the massive growth of international air travel and crowded megacities allow localized outbreaks to become global pandemics faster than ever before. A traveller can cross continents within incubation periods, spreading infections before feeling sick.  

Air travel abets virus transmission by rapidly transporting infected individuals across continents within their incubation periods. In confined aircraft cabins, proximity to infected passengers, prolonged exposure in closed environments, and the circulation of microscopic infectious respiratory particles significantly elevate the risks of spreading pathogens.

It is rightly said that air travel’s greatest threat to global health is its speed. This allows outbreaks to become international pandemics before local health authorities can detect or contain the spread.

It is however interesting to note that transmission is not limited to the flight itself!

High-density areas such as airport security lines, crowded boarding gates, and busy terminals bring large numbers of people from diverse regions into close contact, creating ideal environments for pathogens to spread before passengers even board the flight.

Tarmac isolation and post-flight quarantine protocols were thrust into the global spotlight during the COVID-19 epidemic, fundamentally changing how airports handled passenger disembarkation. These historically specialized, behind-the-scenes public health procedures were suddenly required to scale overnight to manage massive travel repatriations.

It is interesting to note that although many well-known global viruses like SARS-CoV-2 (COVID-19) and Influenza have established origins in Asia, the African continent is considered a hotspot for certain emerging infectious diseases due to its rich biodiversity, climate, and frequent human-animal interactions.

The perception that viruses primarily originate in Africa stems from several specific ecological and social factors.

The continent’s vast ecosystems and tropical climates support a high diversity of wildlife, including bats, rodents, and primates. These animals naturally carry many viruses. When human populations expand into these wild habitats, it increases the chances of viruses ‘jumping’ from animals to humans.  

Besides, close proximity between livestock, wildlife, and human populations - which is often a necessity in subsistence farming and live animal markets - creates fertile ground for viruses to cross species barriers.

“Epidemics and pandemics are increasing in frequency, scale, and economic impact. Given the world’s deeply interconnected economies and supply chains, managing epidemic and pandemic risk has becoming a defining security challenge of our generation.” (Coalition for Epidemic Preparedness Innovations) Viruses become lethal threats to humankind at such breakneck speed because of their unparalleled speed of evolution and ability to exploit the dense, hyper-connected nature of modern human society.

The modern-day practice of attributing every illness to a viral infection is another way of magnifying the dangers of the pathogens. However, doctors attribute the vast majority of everyday, self-limiting sicknesses to viral infections simply because clinical evidence confirms it.

Apparently, humanity has entered a definitive period of coexistence with viruses. We are currently living in an era of unprecedented viral dominance. Driven by rapid mutation rates, high transmissibility, and genetic diversity, viruses have become the planet’s most abundant biological entities.

Virologists and epidemiologists emphasize that while humankind inevitably coexists with endemic viruses, this reality demands ongoing vigilance - not complacency.

Driven by globalization, climate change, habitat encroachment, and advancing biotechnology, the frequent emergence of infectious diseases from nature - alongside accidental or intentional human-induced threats “ is now recognized as a defining, inevitable reality of our modern era.


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